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Patients with idiopathic pulmonary fibrosis acute exacerbation (IPF-AE) who are treated under a protocol free of both immunosuppressants and steroids are significantly more likely to survive the flare than those given these standard treatments, according to data from a study titled “ Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach ,” published in the journal BMC Pulmonary Medicine. IPF-AE is the most severe event during the course of IPF disease, and is ultimately responsible for a worsening in patients conditions and death. While its etiology is still elusive, several triggering factors have been suggested that include infections, gastroesophageal reflux disease, lung surgery, bronchoalveolar lavage, air pollution, and accelerated lung fibrosis. IPF-AE is also associated with diffuse alveolar damage (DAD) resulting in clinical acute respiratory distress syndrome (ARDS) in IPF patients, top 10 hgh. The standard treatment for the condition is steroids and other immunosuppressants (especially azathioprine), although there is no scientific literature on their effectiveness as IPF-AE treatment.
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